Use of the FreeStyle Libre system was associated
with significant reductions in HbA1c that were
sustained for 24 months in adults and children with
T1D and for 12 months in adults with T2D.

A search for relevant publications was conducted across key abstracting and indexing databases.* The search
covered the period from 2013 until December 31^st 2020.

75 studies were identified that reported longitudinal
laboratory HbA1c data in participants with T1D or T2D
using the FreeStyle Libre system over periods from 1 to 24
months. All studies reported data in a manner that could be
used in a statistical meta-analysis.

For randomised controlled trials within the analysis set,
within-intervention arm results were included, but not the
between-arm results reported previously. All studies were
reported as absolute change from baseline to ensure a
consistent approach and to reflect the real-world patient-
centred outcome.

The meta-analysis centred on observed change in HbA1c at 3–4 months and 4.5–7.5 months, as well as a longitudinal
analysis up to 24 months. Mean change in HbA1c adjusted for initial HbA1c was estimated using random effects meta-
regression versus initial HbA1c by type of diabetes with type of diabetes, month, and interaction of type of diabetes and
month as fixed effects. Separate analyses were conducted for adults and children.

Study results were published online in the expert journal Diabetes Therapy in April, 2022.¹