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The IMPACT study was the first randomised controlled trial (RCT) to evaluate the efficacy and safety of the FreeStyle Libre system₼ compared to self-monitoring of blood glucose (SMBG) in adults with well-controlled type 1 diabetes.2
Clinical & Real-world evidence
Learn more about how the FreeStyle Libre portfolio is used in real life by patients and their Health Care Professionals and what results could be achieved.
CATEGORY
All
T1D
IMPACT Study
T1D
FLASH-UK Study
The FLASH-UK study demonstrated that intermittently scanned continuous glucose monitoring (isCGM) with the FreeStyle Libre 2 system provided superior clinical benefits compared to SMBG in people with type 1 diabetes (T1D).3
T2D MDI
Yaron et al. Study
This RCT indicated that using FreeStyle Libre systems in patients with type 2 diabetes on multiple daily injections (MDI) may lead to improved treatment satisfaction and a significant reduction in HbA1c without increasing the risk of hypoglycaemia.4
Gestational diabetes
FLAMINGO Study
The Flamingo RCT analysed the effects of the FreeStyle Libre flash glucose monitoring system₼ compared to SMBG on glycaemic control and perinatal outcomes in pregnant women with gestational diabetes mellitus (GDM).5
T1D / T2D MDI
RELIEF Study (Riveline et al.)
The 24-month follow-up of the RELIEF study6 showed a sustained reduction in hospitalisation rates for acute diabetic events in people with type 1 diabetes (T1D) or type 2 diabetes (T2D) in France.7
T1D / T2D MDI
EVANS et al. Study
This meta-analysis of 75 real-world observational studies observed a significant and sustained reduction in HbA1c with the FreeStyle Libre system₼ in patients with T1D and T2D.8
T2D MDI
REFER Study
The REFER study showed glycaemic benefits, including improved HbA1c, using FreeStyle Libre systems in type 2 diabetes patients managed with basal and bolus insulin in diabetes centres across Europe.9
Type 1 Diabetes
T1D
IMPACT Study
The IMPACT study was the first randomised controlled trial (RCT) to evaluate the efficacy and safety of the FreeStyle Libre system₼ compared to self-monitoring of blood glucose (SMBG) in adults with well-controlled type 1 diabetes.2
T1D
FLASH-UK Study
The FLASH-UK study demonstrated that intermittently scanned continuous glucose monitoring (isCGM) with the FreeStyle Libre 2 system provided superior clinical benefits compared to SMBG in people with type 1 diabetes (T1D).3
T1D / T2D MDI (Pediatrics)
EVANS et al. Study
This meta-analysis of 75 real-world observational studies observed a significant and sustained reduction in HbA1c with the FreeStyle Libre system₼ in patients with T1D and T2D.8
T1D / T2D MDI
RELIEF Study (Riveline et al.)
The 24-month follow-up of the RELIEF study6 showed a sustained reduction in hospitalisation rates for acute diabetic events in people with type 1 diabetes (T1D) or type 2 diabetes (T2D) in France.7
Type 2 Diabetes (Multiple Daily Injections)
T2D MDI
Yaron et al. Study
This RCT indicated that using FreeStyle Libre systems in patients with type 2 diabetes on multiple daily injections (MDI) may lead to improved treatment satisfaction and a significant reduction in HbA1c without increasing the risk of hypoglycaemia.4
T2D MDI
REFER Study
The REFER study showed glycaemic benefits, including improved HbA1c, using FreeStyle Libre systems in type 2 diabetes patients managed with basal and bolus insulin in diabetes centres across Europe.9
T1D / T2D MDI
RELIEF Study (Riveline et al.)
The 24-month follow-up of the RELIEF study6 showed a sustained reduction in hospitalisation rates for acute diabetic events in people with type 1 diabetes (T1D) or type 2 diabetes (T2D) in France.7
T1D / T2D MDI (Paediatrics)
EVANS et al. Study
This meta-analysis of 75 real-world observational studies observed a significant and sustained reduction in HbA1c with the FreeStyle Libre system₼ in patients with T1D and T2D.8
Paediatrics
T1D / T2D MDI (Paediatrics)
EVANS et al. Study
This meta-analysis of 75 real-world observational studies observed a significant and sustained reduction in HbA1c with the FreeStyle Libre system₼ in patients with T1D and T2D.8
Gestational Diabetes
Gestational diabetes
FLAMINGO Study
The Flamingo RCT analysed the effects of the FreeStyle Libre flash glucose monitoring system₼ compared to SMBG on glycaemic control and perinatal outcomes in pregnant women with gestational diabetes mellitus (GDM).5
CATEGORY
All
T1D
IMPACT Study
The IMPACT study was the first randomised controlled trial (RCT) to evaluate the efficacy and safety of the FreeStyle Libre system₼ compared to self-monitoring of blood glucose (SMBG) in adults with well-controlled type 1 diabetes.2
T2D MDI
Yaron et al. Study
This RCT indicated that using FreeStyle Libre systems in patients with type 2 diabetes on multiple daily injections (MDI) may lead to improved treatment satisfaction and a significant reduction in HbA1c without increasing the risk of hypoglycaemia.4
T1D
FLASH-UK Study
The FLASH-UK study demonstrated that intermittently scanned continuous glucose monitoring (isCGM) with the FreeStyle Libre 2 system provided superior clinical benefits compared to SMBG in people with type 1 diabetes (T1D).3
Gestational Diabetes
FLAMINGO Study
The Flamingo RCT analysed the effects of the FreeStyle Libre flash glucose monitoring system₼ compared to SMBG on glycaemic control and perinatal outcomes in pregnant women with gestational diabetes mellitus (GDM).5
Type 1 Diabetes
T1D
IMPACT Study
The IMPACT study was the first randomised controlled trial (RCT) to evaluate the efficacy and safety of the FreeStyle Libre system₼ compared to self-monitoring of blood glucose (SMBG) in adults with well-controlled type 1 diabetes.2
T1D
FLASH-UK Study
The FLASH-UK study demonstrated that intermittently scanned continuous glucose monitoring (isCGM) with the FreeStyle Libre 2 system provided superior clinical benefits compared to SMBG in people with type 1 diabetes (T1D).3
Type 2 Diabetes (Multiple Daily Injections)
T2D MDI
Yaron et al. Study
This RCT indicated that using FreeStyle Libre systems in patients with type 2 diabetes on multiple daily injections (MDI) may lead to improved treatment satisfaction and a significant reduction in HbA1c without increasing the risk of hypoglycaemia.4
Gestational Diabetes
Gestational Diabetes
FLAMINGO Study
The Flamingo RCT analysed the effects of the FreeStyle Libre flash glucose monitoring system₼ compared to SMBG on glycaemic control and perinatal outcomes in pregnant women with gestational diabetes mellitus (GDM).5
CATEGORY
All
T1D / T2D MDI
RELIEF Study (Riveline et al.)
The 24-month follow-up of the RELIEF study6 showed a sustained reduction in hospitalisation rates for acute diabetic events in people with type 1 diabetes (T1D) or type 2 diabetes (T2D) in France.7
T1D / T2D MDI (Paediatrics)
EVANS et al. Study
This meta-analysis of 75 real-world observational studies observed a significant and sustained reduction in HbA1c with the FreeStyle Libre system₼ in patients with T1D and T2D.8
T2D MDI
REFER Study
The REFER study showed glycaemic benefits, including improved HbA1c, using FreeStyle Libre systems in type 2 diabetes patients managed with basal and bolus insulin in diabetes centres across Europe.9
Type 1 Diabetes
T1D (Paediatrics)
RELIEF Study (Riveline et al.)
The 24-month follow-up of the RELIEF study6 showed a sustained reduction in hospitalisation rates for acute diabetic events in people with type 1 diabetes (T1D) or type 2 diabetes (T2D) in France.7
T1D / T2D MDI (Paediatrics)
EVANS et al. Study
This meta-analysis of 75 real-world observational studies observed a significant and sustained reduction in HbA1c with the FreeStyle Libre system₼ in patients with T1D and T2D.8
Type 2 Diabetes (Multiple Daily Injections)
T2D MDI
REFER Study
The REFER study showed glycaemic benefits, including improved HbA1c, using FreeStyle Libre systems in type 2 diabetes patients managed with basal and bolus insulin in diabetes centres across Europe.9
T1D / T2D MDI (Paediatrics )
EVANS et al. Study
This meta-analysis of 75 real-world observational studies observed a significant and sustained reduction in HbA1c with the FreeStyle Libre system₼ in patients with T1D and T2D.8
T1D / T2D MDI
RELIEF Study (Riveline et al.)
The 24-month follow-up of the RELIEF study6 showed a sustained reduction in hospitalisation rates for acute diabetic events in people with type 1 diabetes (T1D) or type 2 diabetes (T2D) in France.7
Paediatrics
T1D / T2D MDI (Paediatrics)
EVANS et al. Study
This meta-analysis of 75 real-world observational studies observed a significant and sustained reduction in HbA1c with the FreeStyle Libre system₼ in patients with T1D and T2D.8
Disclaimer & References
Images are for illustrative purposes only. Not real healthcare professionals.
₼ Sale of the original FreeStyle Libre system has been discontinued in EU & UK markets. In these markets, the FreeStyle Libre 2 and 3 systems are for sale, providing the same benefits as the original FreeStyle Libre system, with the added functionalities of optional Real-Time Alarms.
1. Wilmot E., Lancet Diabetes Endocrinol. (2026). https://doi.org/10.1016/S2213-8587(26)00076-8.
2. Bolinder J., Lancet. (2016): https://doi.org/10.1016/S0140-6736(16)31535-5.
3. Leelarathna, L. N Engl J Med. (2022): DOI: 10.1056/NEJMoa2205650.
4. Yaron, M. Diabetes Care (2019): https://doi.org/10.2337/dc18-0166.Campbell, FM. Pediatr Diabetes (2018): https://doi.org/10.1111/pedi.12735.
5. Majewska, A. Acta Diabetol (2023): https://doi.org/10.1007/s00592-023-02091-2. Epub 2023 May 10.
6. Roussel R., Diabetes Care. (2021): https://doi.org/10.2337/dc20-1690.
7. Riveline, JP. Diabetes Technol Ther (2022): https://doi.org/10.1089/dia.2022.0085.
8. Evans M., Diabetes Ther. (2022): http://doi.org/10.1007/s13300-022-01253-9.
9. Kroger J., Diabetes Ther (2020): https://doi.org/10.1007/s13300-019-00741-9.
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