The hidden cardiovascular burden in type 2 diabetes

When hypoglycaemia goes unnoticed, so can cardiovascular risk

Join Professors Ramzi Ajjan and Rayaz Malik as they explore why maintaining average glucose levels isn't enough to prevent cardiovascular and microvascular complications.

Data highlights

7-12x Higher risk of MACE & mortality

Severe hypoglycaemia increases the risk of Major Adverse Cardiovascular Events (MACE) and all-cause mortality by 7 to 12-fold in the first week after the event, this elevated risk is not just instantaneous, but it also persists after the hypoglycemic episode has resolved.1 

 

28% Lower risk of nerve fibre loss

Corneal Confocal Microscopy (CCM) analysis reveals that a 10% increase in Time in Range (TIR) is associated with a 28% reduction in the risk of abnormal corneal nerve fibre length.2

 

16% Lower risk of CV events

In a real-world observational study of adults with type 2 diabetes, continuous glucose monitoring (CGM) use was associated with a 16% lower risk of cardiovascular events (HR 0.84) and a 21% lower risk of mortality (HR 0.79) compared to matched non-users.3

HR: Hazard Ratio

31.9% asymptomatic hypoglycaemia rate

In a study of people with type 2 diabetes, 31.9% of the population experienced asymptomatic hypoglycaemia during the daytime, highlighting how frequently these episodes go undetected.4
 

 

Libre technology is linked to reduced hospitalisations for cardiovascular complications in adults with diabetes.5,6

The FreeStyle Libre 2 system is clinically proven to increase Time In Range and reduce time spent in hypoglycaemia.7

Explore our dedicated Libre Hub for everything you need to get patients started and prescribe the FreeStyle Libre 2 system.

Need support? Our Abbott representatives are here to help, whether you have questions about getting patients started, need guidance on prescribing, or want to explore the evidence behind FreeStyle Libre. Fill out our short form and we'll arrange a meeting at a time that suits you.

 

Patient and healthcare professional having a conversation

Additional resources

Education, Case Studies & Training

Discover a library of different resources to help you improve your knowledge of the Libre Products, facilitate peer-to-peer discussions, as well as materials to support you with your patient training

Webinars

Explore our on-demand webinars as well as upcoming live webinars that give you the opportunity to learn and ask questions about the Libre products and glucose-monitoring technology.

Triangle of Diabetes Care

Developed by Prof. Ramzi Ajjan, one of the speakers in the video, the Triangle of Diabetes Care outlines three targets for better diabetes management.
 

References & Disclaimers

Images are for illustrative purposes only. Not real patients, data or healthcare professional.

1. Zinman B, Marso SP, Christiansen E, et al. Hypoglycemia, Cardiovascular Outcomes, and Death: The LEADER Experience. Diabetes Care. 2018;41(8):1783-1791. doi:10.2337/dc17-2677

2. Zhao W, Lu J, Zhang L, et al. Relationship between time in range and corneal nerve fiber loss in asymptomatic patients with type 2 diabetes. Chin Med J (Engl). 2022;135(16):1978-1985. Published 2022 Aug 20. doi:10.1097/CM9.0000000000002140

3. Reaven PD, Macwan S, Newell M, et al. Initiation of Continuous Glucose Monitoring and Mortality in Type 2 Diabetes. Diabetes Technol Ther. 2025;27(10):778-789. doi:10.1089/dia.2025.0227

4. Huang, B., Jiang, Q., Wu, T. et al. Hypoglycemia unawareness identified by continuous glucose monitoring system is frequent in outpatients with type 2 diabetes without receiving intensive therapeutic interventions. Diabetol Metab Syndr 14, 180 (2022). https://doi.org/10.1186/s13098-022-00959-x

5. Eeg, Olofsson, K. Diabetes Care (2024). https://doi.org/10.2337/dc24-0690

6. Nathanson, D. Diabetologia (2025). https://doi.org/10.1007/s00125-024-06289-z

7. Leelarathna, L. N Engl J Med. (2022): DOI: 10.1056/NEJMoa2205650

 

ADC-128365 v1.0

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