Ambulatory Glucose Profile

The Ambulatory Glucose Profile (AGP) is an internationally recognised way of summarising and visualising large amounts of glycaemic data in a clinically meaningful format.1 It can be used to review glycaemic control with each of your patients and can help you focus on aspects of their glycaemic control to support their daily diabetes management.

An HCP showing their patient the AGP
An HCP showing their patient the AGP
An HCP showing their patient the AGP

Introduction

There are four key components of an AGP:

  • Median
  • 25th–75th Percentile
  • 5th–95th Percentile
  • Target Glucose Range

Each of these elements tells a clear story about your patients’ glucose control and variability over a selected time period.

BLACK/BLUE SOLID LINE: Median Line

The median line traces the mid-point glucose reading as a measure of average glucose at each point in the modal day and shows whether the average glucose is within the target glucose range and how much it oscillates during the day.2 The goal for the Median Line is for it to be as flat as possible over the entire 24 hours period and within the target glucose range.

INNER BLUE-SHADED BAND: 25th to 75th Percentile

The 25th to 75th Percentile band illustrates when glucose variation is common from one day to the next. The band represents 50% of all glucose readings for the patient at each time point. The goal is reduce the more-common day-to-day glucose variability by reducing the width of the 25th to 75th Percentile above and below the median line.

OUTER GREY-SHADED BAND: 5th to 95th Percentile

The visible part of the 5th to 95th percentile includes the readings that reflect less common departures from the daily average glucose. Large excursions above or below the Median Line may indicate poor control for a variety of reasons, but if the 5th to 95th percentile band is wide it means that occasionally your patient's glucose control has varied quite a lot from day to day. The goal is to understand if more extreme glucose readings can be linked to occasional activities that a patient can plan for.

TWO PARALLEL LINES: Target Glucose Range

This is the corridor where glucose levels should be as much as possible. According to international consensus, the target glucose range is usually 3.9 mmol/L–10 mmol/L for adults with type 1 and type 2 diabetes who are not pregnant, not older, or at risk.1

The benefits of reviewing AGP

The core values of the Ambulatory Glucose Profile (AGP) Include:3

✓ Detect daily glucose variabilities that can not be displayed by HbA1c.

✓ Assessing a patient's glucose levels versus target range.

✓ Understanding extent and causes of high glucose variability.

✓ Assessing suitability of treatment.

✓ Assessing whether there is a need to adapt insulin doses.

✓ Is useful for helping patients understand their glycaemic control.

✓ Is useful for helping a patient's overall understanding of their diabetes.

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Learn about AGP in practice and discover our 4-Step Guide to Managing an AGP Review

AGP & LibreView

Easily visualise AGP for your patients with LibreView₼,4

LibreView is a secure,5 cloud-based diabetes management system. It provides both healthcare professionals and patients with access to a consistent set of clear, intuitive reports that make it easier and faster to discover patterns and trends.4

With the AGP report on LibreView you can:

  • See Time in Target guidelines and an overview of patient glucose data
  • Quickly assess your patient’s AGP
  • Identify trends and patterns at a glance
  • Identify specific times of deviation with the Daily Glucose Profiles

Additional Resources

Training Resources

Explore our training resources to help you to
help your patients understand the Ambulatory
Glucose Profile.

References & Disclaimers

Images are for illustrative purposes only. Not real patients, healthcare professionals or data.

1. Battelino T, Danne T, Bergenstal RM, et al. Clinical targets for continuous glucose monitoring data interpretation: recommendations from the international consensus on time in range. Diabetes Care. (2019);42(8):1593-1603. 

2. Doupis J, Horton ES. TouchREVIEWS in endocrinology vol. 18,1 (2022): 20-26. doi:10.17925/EE.2022.18.1.20). 

3. Matthaei, S.Br J Diabetes Vasc Dis 2014, 4:148-152.

4. The LibreView data management software is intended for use by both patients and healthcare professionals to assist people with diabetes and their healthcare professionals in the review, analysis and evaluation of historical glucose meter data to support effective diabetes management. The LibreView software is not intended to provide treatment decisions or to be used as a substitute for professional healthcare advice.

5. LibreView is ISO27001/27018/27701 certified and HITRUST CSF Certified. 

₼ The LibreView website is only compatible with certain operating systems and browsers. Please check www.LibreView.com for additional information.

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