Clinical Evidence

Clinical benefits for a broad range of T1D and T2D patients

A FreeStyle Libre System Healthcare Professional smiling.
A FreeStyle Libre System Healthcare Professional smiling.
A FreeStyle Libre System Healthcare Professional smiling.

Increased Time in Range

The FreeStyle Libre systems are proven to increase %TIR*,1

2.2 hours more Time in Range per day in T1D1

An independent study published in the New England Journal of Medicine shows that FreeStyle Libre 2 users increased their Time in Range by over 2 hours per day.

  • 156 people with T1D ≥16 years with HbA1c >7.5% to 7.5%-11% participated in a randomised, controlled study

  • FreeStyle Libre 2 users spent 2.2 hours more time in range per day at 6 months of use vs those using self-monitored blood glucose
Time in range chart

Reduced HbA1c

The FreeStyle Libre systems are clinically proven to significantly reduce HbA1c*,1,2,3

HbA1c reduction in T1D

Significant HbA1c reduction in T1D1

The same independent study shows that FreeStyle Libre users reduced their HbA1c by 0.5% compared to self-monitored blood glucose at 6 months of use.


HbA1c reduction in T2D on MDIs


HbA1c reduction for T2DM on MDIs
at 10 weeks of use2

vs -0.33% with BGM (p=0.005)
RCT of n=101 people with T2DM on MDI therapy


HbA1c reduction for T2DM
on rapid- or short-acting insulin3

p<0.0001 vs baseline
Meta-analysis of data from 18 medical centres in Austria, France and Germany

Reduced time in hypoglycaemia

The FreeStyle Libre systems are clinically proven to reduce time in hypoglycaemia in T1D1 and T2D on MDIs4,*


43 minutes

less time in hypoglycaemia per day1

T2D on MDIs


reduction in time spent in hypoglycaemia4

(<3.9 mmol/L)

Making Better Choices

The FreeStyle Libre portfolio helps patients with T1D and T2D make better choices

Better understanding of glucose fluctuations:

Real World data showed that 95% of patients with T1D and T2D using the FreeStyle Libre system have a better understanding of their glucose fluctuations.5

Lifestyle modifications can help lower HbA1c

Patients with T2D who make lifestyle changes, such as diet and physical activity, see improved glucose control.6

A woman and a man with mugs in their hands sitting at the table full of food.

Improved Glycaemic Control in ChildrenѰ

Children and teenagers can successfully improve their glycaemic control with the FreeStyle Libre portfolio

1 hr/day

increase in time in range 

(3.9–10.0 mmol/L)


reduction in HbA1c7

1.2 hr/day

less time spent in hyperglycaemia7

(>10 mmol/L) with no significant increase in time spent in hypoglycaemia (<3.9 mmol/L)


of children and teenagers agreed that the FreeStyle Libre system did not get in the way of daily activities7

Additional Resources

Real-World Data

Analysing the impact of the FreeStyle Libre portfolio on the lives of real users.

Educational Modules

Learn more about Time in Range and the FreeStyle Libre portfolio through our Healthcare Professional educational modules.


We offer various on-demand webinars for Healthcare Professionals including a spotlight on hypoglycaemia.


Webcast Series

Learn more about Time in Range in our CME accredited three-module webcast series.


Training Resources

Explore our training resources to help you to help your patients understand Time in Range better.

References & Disclaimers

Images are for illustrative purposes only. Not real patient or data.

* FreeStyle Libre systems refers to the FreeStyle Libre 2 and FreeStyle Libre 3 systems. The data from this study was collected using the FreeStyle Libre 2 system. FreeStyle Libre 3 system has the same features as the FreeStyle Libre 2 system therefore the study data is applicable to both products.

Ѱ For children aged 4-12, a caregiver at least 18 years old is responsible for supervising, managing, and assisting them in using the FreeStyle Libre system and interpreting its readings.

1. Leelarathna, L. N Engl J Med. (2022): DOI: 10.1056/NEJMoa2205650.

2. Yaron M, et al. Effect of flash glucose monitoring technology on glycemic control and treatment satisfaction in patients with type 2 diabetes. Diabetes Care 2019;42(7):1178–84.

3. Kröger J, et al. Three European retrospective real-world chart review studies to determine the effectiveness of flash glucose monitoring on HbA1c in adults with type 2 diabetes. Diabetes Ther 2020;11(1):279–91.

4. Haak T, et al. Flash glucose-sensing technology as a replacement for blood glucose monitoring for the management of insulin-treated type 2 diabetes: a multicenter, open-label randomized controlled trial. Diabetes Ther 2017;8(1):55–73.

5. Fokkert M, van Dijk P, Edens M, et al. Improved well-being and decreased disease burden after 1-year use of flash glucose monitoring (FLARE-NL4). BMJ Open Diab Res Care. 2019. https://doi:10.1136/bmjdrc-2019-000809.

6. American Diabetes Association Professional Practice Committee. 5. Facilitating behavior change and well-being to improve health outcomes: Standards of Medical Care in Diabetes—2022. Diabetes Care 2022;45 (Suppl. 1):S60–S82.

7. Campbell FM, et al. Outcomes of using flash glucose monitoring technology by children and young people with type 1 diabetes in a single arm study. Pediatr Diabetes 2018;19(7):1294–301.